General Information

  • ID:  hor003832
  • Uniprot ID:  P19402
  • Protein name:  NPP
  • Gene name:  pomc
  • Organism:  Cavia porcellus (Guinea pig)
  • Family:  POMC family
  • Source:  animal
  • Expression:  ACTH and MSH are produced by the pituitary gland.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Cavia (genus), Caviidae (family), Hystricomorpha (suborder), Rodentia (order), Glires, Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  WCLESSQCQDLTTERHLLECLRACKPDLSAETPVFPGGADEQTPTESPRKYVTGHFRWGRFGRGNSSGASQ
  • Length:  71
  • Propeptide:  MPRSCYSRSGTLLLALLLQISMEVRGWCLESSQCQDLTTERHLLECLRACKPDLSAETPVFPGGADEQTPTESPRKYVTGHFRWGRFGRGNSSGASQKREEEAAAADPGFHGDGVEPGLREDKRSYSMEHFRWGKPVGKKRRPVKVYANGAEEESAEAFPLEFKRELTGERPAAAPGPDGLGFGLVAEAEAEAAAAEKKDAAEKKDDGSYRMEHFRWGTPRKGKRYGGFMTSEKSQTPLVTLFKNAIVKNAHKKGQ
  • Signal peptide:  MPRSCYSRSGTLLLALLLQISMEVRG
  • Modification:  T61 Phenylalanine amide
  • Glycosylation:  T45 O-linked (GalNAc...) threonine;T65 N-linked (GlcNAc...) asparagine
  • Mutagenesis:  NA

Activity

  • Function:  ACTH stimulates the adrenal glands to release cortisol.; MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes.; Beta-endorphin and Met-enkephalin are endogenous opiates.; [Corticotropin]: Stimulates the adrenal glands to release cortisol.; [Melanocyte-stimulating hormone alpha]: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.; [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes.; [Beta-endorphin]: Endogenous orexigenic opiate.; [Met-enkephalin]: Endogenous opiate.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  Mc4r, Mc2r
  • Target Unid:  A8QXQ6, Q9Z1S9
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  2-24
  • Structure ID:  AF-P19402-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor003832_AF2.pdbhor003832_ESM.pdb

Physical Information

Mass: 913344 Formula: C338H520N102O109S4
Absent amino acids: IM Common amino acids: GSELRT
pI: 6.49 Basic residues: 10
Polar residues: 26 Hydrophobic residues: 17
Hydrophobicity: -80.42 Boman Index: -17498
Half-Life: 2.8 hour Half-Life Yeast: 3 min
Half-Life E.Coli: 2 min Aliphatic Index 46.76
Instability Index: 6490.56 Extinction Coefficient cystines: 12740
Absorbance 280nm: 182

Literature

  • PubMed ID:  1662166
  • Title:  Molecular Cloning and Sequencing of a Guinea-Pig Pro-Opiomelanocortin cDNA